Work

Long-term interleukin-4 release from 3D printable affinity hydrogels promotes M2-like macrophage polarisation in vitro

Year: 2025

Type: article

Abstract: . We manufactured SPAK-PEGDA hydrogels by projection micro stereolithography, in which 3D printed 5% SPAK-10% PEGDA had an increased lysozyme release rate compared to its cast counterpart. 3D printed 5% SPAK-10% PEGDA with porous 3D design had an increased lysozyme release rate compared to a volume matched non-porous design. These findings highlight the potential of SPAK-PEGDA hydrogels for long-term cytokine delivery and show proof-of-concept for manipulating protein release kinetics with 3D printed hydrogel design.

Source: Biomaterials Science

DOI: 10.1039/d4bm01623h

Authors: George A. Loxley, Consuelo Coser, Amir M. Ghaemmaghami, Jing Yang

Institutions: University of Nottingham, University of Surrey

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Nottingham, Medical Research Council, Engineering and Physical Sciences Research Council