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A case report unveiling spindle cell lipoma

Year: 2025

Type: article

Abstract: Spindle cell lipoma (SCL) represents an infrequent subtype of lipoma distinguished by its distinctive histopathological characteristics and tendency to localize in the subcutaneous tissues of the upper back, neck, and shoulder regions. In this report, we describe an unusual instance of SCL manifesting in the cervical area of a 62-year-old female individual. The patient exhibited a progressively enlarging painless mass situated in the left supraclavicular region for 8 years. Radiographic assessments disclosed a clearly demarcated, enclosed mass indicative of a lipomatous lesion. Microscopic analysis of the surgically removed specimen verified the presence of SCL, featuring mature adipocytes interspersed with spindle cells and collagen fibers. Subsequent immunohistochemical testing corroborated the diagnosis through the detection of CD34 positivity and S-100 protein negativity. Subsequent to surgical excision, the patient experienced an uneventful recovery period, devoid of any signs of recurrence throughout the monitoring phase. Despite its rarity, SCL should be contemplated in the differential diagnosis of neck masses, particularly when radiological findings point towards adipose tissue-related neoplasms. Timely identification and suitable intervention play a pivotal role in ensuring positive prognoses for individuals afflicted with SCL in the neck region.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.03.009