Work

Effects of different embryonic development days on clinical outcomes of freeze-thawed embryo transfer

Year: 2025

Type: article

Abstract: Objective: To compare the clinical outcome of freeze-thawed embryo transfer at different embryonic development days in whole embryo freezing patients of different ages. Methods: This was a retrospective study. Collected clinical data of 558 patients who underwent freeze-thawed embryo transfer at Reproductive Center of Baoding Maternal and Child Health Hospital from March 2019 to January 12, 2022. The enrolled patients were divided into two groups of 21~35 years old group(n=421) and 35~50 years old group(n=137) according to their ages. Then, three subgroups were established according to the development days of the freeze-thawed embryos under different age groups, D3 subgroup, D5 subgroup and D6 subgroup. Results: There were no significant differences in biochemical pregnancy rate, clinical pregnancy rate, multiple pregnancy rate, abortion rate, among the three groups in the 21~35 years old group. While significant difference was observed the highest embryo implantation rate in D5 subgroup(P<0.05). Meanwhile, in 35~50 years old group, the biochemical pregnancy rate in D5 subgroup was significantly higher than that in D3 and D6 subgroups(P<0.05). The clinical pregnancy rate of D5 subgroup was significantly higher than that of D6 subgroup(P<0.05), and the clinical pregnancy rate of D5 subgroup was higher than that of D3 subgroup(P>0.05). The embryo implantation rate in D5 subgroup was significantly higher than that in D3 and D6 subgroups(P<0.05). Conclusion: Compared with D3 and D6 transfer strategies, D5-blastocyst transfer exhibits more satisfactory clinical outcomes, with the highest clinical pregnancy and embryo implantation rates. doi: https://doi.org/10.12669/pjms.41.4.9634 How to cite this: Meng NN, Li PT, Liu T, Zhai JW, Guo MY. Effects of different embryonic development days on clinical outcomes of freeze-thawed embryo transfer. Pak J Med Sci. 2025;41(4):1087-1091. doi: https://doi.org/10.12669/pjms.41.4.9634 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Source: Pakistan Journal of Medical Sciences

DOI: 10.12669/pjms.41.4.9634

Authors: Nana Meng, Pengtao Li, Ting Liu, Jiawei Zhai, Meng-yuan Guo

Institutions: Nantong Maternity and Child Health Hospital, Shaoxing City Women and Children Hospital

Language: English

Topic: Reproductive Biology and Fertility

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $400