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Immunomodulatory Effects Of Lactobacillus Plantarum NC8 In Poultry: Enhancing Immune Response Against Salmonellosis

Year: 2025

Type: article

Abstract: Salmonella Gallinarum is a major pathogen in poultry, causing fowl typhoid and significant economic losses. This study investigates the immunomodulatory effects of Lactobacillus plantarum NC8 in enhancing resistance against S. Gallinarum infection. A total of 45 chicks were divided into experimental groups and administered different doses of L. plantarum NC8. Birds that received a double-dose regimen (Day 1 and Day 10) revealed reduced tissue damage in the vaccinated groups compared to controls in histopathological analysis. The expression of key cytokines (IL-4, IL-10, and IL-17) was significantly upregulated, suggesting a balanced immune response that enhances both protection and immune regulation. These findings highlight the potential of Lactobacillus plantarum NC8 as a probiotic intervention to improve poultry immunity and reduce Salmonella infections, offering a natural and sustainable alternative to antibiotics in disease control.

Source: South Eastern European Journal of Public Health

DOI: 10.70135/seejph.vi.4951

Authors: Junaid Nazir, Shazia Tabassum, Saima Tabassum, Areeba Tabassum, Priyanka J Ha, Syed Mudasir Ahmad

Institutions: Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Government Medical College, Government Medical College

Language: English

Topic: Probiotics and Fermented Foods

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: diamond

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Science and Engineering Research Board