Work

Creatine metabolism in psychosis and catatonia: A case report and review of the literature

Year: 2025

Type: article

Abstract: Background In the below case report, we describe the development of psychotic and catatonic symptoms in an individual with Arginine-Glycine-Amindinotransferase (AGAT) deficiency, requiring creatine supplementation. Basic Procedures and Main Findings We have conducted a literature review and to our knowledge this is the first documented instance of psychiatric symptoms of this kind developing in an individual with AGAT deficiency. Principal Conclusions This case provides clinical support for the role of brain creatine metabolism in the development of psychotic and catatonic symptoms.

Source: Psychiatry Research Case Reports

DOI: 10.1016/j.psycr.2025.100260

Authors: Sophie Scharner, Terrance M Dolan, Eric P Hazen

Institutions: Harvard University, Massachusetts General Hospital

Language: English

Topic: Metabolism and Genetic Disorders

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $950