Year: 2025
Type: article
Study design: Case Report
Abstract: This case report presents a 48-year-old woman with a history of chronic kidney disease who experienced toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, an uncommon and severe adverse drug reaction. The TEN was attributed to the use of non-steroidal anti-inflammatory drugs (NSAIDs). Cutaneous involvement exceeded 80% of the body surface area (BSA), encompassing ocular, oral, and nasal mucosa, as well as the trunk, bilateral limbs, and genitalia. Treatment commenced with aggressive fluid resuscitation, the administration of cyclosporine, and meticulous dermal care. The patient was ultimately discharged following approximately one month of intensive therapy.
Authors: Lahari Samudrala, Bhanu Pratap Singh, Rajya Laxmi Papasani, Tharun Bashaboina, Ramarao Tadikonda
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408935031