Work

Episodes of Keratitis during Treatment with Baricitinib for Alopecia Areata

Year: 2025

Type: article

Abstract: Introduction: There is scarce evidence in the literature regarding the association of JAK inhibitors and keratitis. Case Presentation: We present the case of a 33-year-old woman with alopecia areata who developed 3 episodes of keratitis within 2 months of treatment with baricitinib, a JAK1/JAK2 inhibitor, and had to therefore stop treatment with baricitinib. Conclusion: On review of the literature regarding ocular side effects with JAK inhibitors, these seem rare but not exceptional. At this time, a casual link cannot be established. To exercise caution, clinicians should be aware of possible ocular adverse events in patients using JAK inhibitors and should also report these cases to the relevant drug safety agencies. Discontinuing the drug and switching to an alternative agent may also be necessary.

Source: Skin Appendage Disorders

DOI: 10.1159/000544920

Authors: Dorottya Godor, Anastasia Therianou

Institutions: University Hospital of Wales, Imperial College Healthcare NHS Trust

Language: English

Topic: Drug-Induced Ocular Toxicity

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4408937916