Work

Dual‐Responsive Phosphorus‐Based Fluorescent Sensors: Synthesis and Selective Metal Sensing of Pyrazolyl Phosphine Oxides

Year: 2025

Type: article

Abstract: Despite a wealth of previously reported frameworks for fluorescent metal sensors, there are few examples of phosphorus‐based fluorophores being used in metal sensing applications. Here, we report the synthesis and characterization of a new family of pyrazolyl phosphine oxides and their use in metal sensing applications. The mechanism of their formation has been probed in detail with both computational and experimental studies, rationalizing the selectivity of the reaction. Their use as dual‐responsive fluorescent metal sensors is then demonstrated, with “turn‐off” and “turn‐on” responses observed for Fe 3+ and Al 3+ , respectively. These systems exhibit good selectivity, large Stokes shifts, and submicromolar limits of detection and will open new avenues in phosphorus‐based fluorophores and metal‐sensing applications.

Source: Angewandte Chemie

DOI: 10.1002/ange.202501421

Authors: Ethan D. E. Calder, Isobel R. J. Hawes, Andrew R. Jupp

Institution: University of Birmingham

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,790

Funders: Royal Society, University of Birmingham, Engineering and Physical Sciences Research Council