Prevalence of Duffy Null and Its Impact on Hydroxyurea Dosing in Children With Sickle Cell Disease
Year: 2025
Type: article
Study design: Observational Study
Abstract: Duffy null phenotype is common in people of African ancestry and is associated with lower baseline white blood cell (WBC) and neutrophil counts. We evaluated whether the presence of the Duffy null phenotype had any association with neutropenia in our patients with sickle cell disease on hydroxyurea (HU). We found a statistically significant difference (p = 0.006) in HU maximum tolerated dose (MTD) in patients with Duffy null phenotype compared with Duffy-positive individuals. Our study suggests that careful dose escalation is warranted in Duffy-null individuals.
Source: Pediatric Blood & Cancer
DOI: 10.1002/pbc.31693
Authors: Jill S. Menell, S. Raelle Jackson, Alissa R. Kahn, William C. Woolbright, Leya Y. Schwartz, John Norko
Institutions: St. Joseph’s Children’s Hospital, St. George's University
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4408941046