Work

Age-related differences in coronary artery lesions and short-term prognosis in acute coronary syndrome patients

Year: 2025

Type: article

Abstract: OBJECTIVE: To explore age-related differences in coronary artery lesions, lesion characteristics, and short-term prognosis in acute coronary syndrome (ACS) patients. METHODS: A retrospective analysis was conducted on 198 ACS patients (February 2019-January 2024). Patients were grouped by age: < 40 years (low-age), 40-60 years (middle-age), and > 60 years (high-age). We compared clinical data, coronary angiography results, lesion characteristics, and short-term major adverse cardiac event (MACE) occurrence across the groups. Pearson or Spearman correlation was used to assess relationships, and ROC curves were employed to evaluate the predictive ability for MACE. RESULTS: The high-age group had significantly higher Gensini scoring and Global Registry of Acute Coronary Events (GRACE) scores (both P < 0.001), more diseased branches, and a higher proportion of non-calcified plaques. MACE incidence was highest in the high-age group. Age correlated positively with hypertension, hyperlipidemia, triglycerides, Gensini score, GRACE score, and the number of diseased branches, and negatively with hemoglobin levels (all P < 0.05). Age showed the strongest predictive ability for short-term MACE (AUC: 0.673, sensitivity: 71.0%). CONCLUSION: Elderly ACS patients exhibit more severe coronary lesions and a higher incidence of MACE. Age is a significant predictor of short-term MACE and correlates with various clinical and angiographic indicators.

Source: American Journal of Translational Research

DOI: 10.62347/tyyq6633

Author: Qiaoxi Hu

Institutions: Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Coronary Interventions and Diagnostics

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4408946665