Work

Enantioselective Spirocyclization of Pd‐Enolates and Isocyanates

Year: 2025

Type: article

Abstract: An enantioselective cyclization of Pd-enolates and isocyanates to form spirocyclic γ-lactams is reported. This reaction proceeds under mild reaction conditions and utilizes a novel Meldrum's acid derivative to achieve catalyst turnover, delivering enantioenriched products in up to 97% yield and 96% ee. Preliminary mechanistic investigations suggest that the reaction may proceed via the formation of higher-order species.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202502583

Authors: Jay P. Barbor, Kaylin N. Flesch, Melinda Chan, Hannah R. Ang, Brian M. Stoltz

Institution: California Institute of Technology

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: G2107332241