Work

Impact of Chloride Ion Channel Clc4 on Bladder Cancer Progression

Year: 2025

Type: article

Abstract: Oncogene and tumour suppressor gene mutations cause heterogeneous cancer. About 10 million people die due to cancer annually. Bladder cancer is one of the most common cancers worldwide, predominantly in men. It is reported that ion channels are involved in cell proliferation, differentiation, apoptosis, tumour cell motility, invasion, and metastasis; hence, cancers are channelopathies. This study examined the expression of chloride ion channel CLC4 in bladder cancer. We collected 20 pairs of tumours and normal tissue samples from bladder cancer patients for the expression analysis. We observed an increase in CLC4 mRNA expression. Mutations in CLC4 gene cause chloride ion channel changes that promote cancer. Understanding chloride channel molecular mechanisms require more research.

Source: Journal of medical & health sciences review.

DOI: 10.62019/k39cnw92

Authors: Roshan Afshan MD, Rukhsar Ali Shah, Walid khan, Ashraf Ali, Muhammad Asif, Ahtasham Akbar, Hiba Noor

Institutions: Wayne State University, Detroit Medical Center, Riphah International University, Hayatabad Medical Complex, Khyber Medical University, Shifa Tameer-e-Millat University, COMSATS University Islamabad

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4408955828

FWCI:

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