Exploring the Impact of Click Chemistry on Carbohydrate Derivatives and their Biological Properties
Year: 2025
Type: article
Abstract: The application of click chemistry in the synthesis of intricate carbohydrate derivatives has revolutionized the domains of chemical biology and synthetic chemistry. This review examines the function of click chemistry, namely the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), in effectively altering carbohydrate structures and producing practical glycoconjugates. Carbohydrates are essential in several biological functions, such as cellular recognition and immunological responses, however, their complicated structure makes production difficult. Click chemistry provides an optimal answer to these issues due of its simplicity, high yields and bioorthogonality. This methodology has been extensively used in the advancement of glycoproteins, glycodendrimers and glycopeptides, which play a crucial role in the fields of drug discovery, vaccine development and diagnostics. In addition, click chemistry has facilitated the development of biodegradable polymers and glycomacromolecules that have the potential to be used in materials science, namely for sustainable materials and smart technology. The flexibility and accuracy of CuAAC in producing carbohydrate-based structures provides new opportunities for investigation, stimulating advancements in both biomedicine and industrial applications. This evaluation also emphasizes the capacity of click chemistry to expedite the advancement of multifunctional therapeutic drugs that target intricate ailments like cancer.
Source: Asian Journal of Chemistry
Authors: Dipali G. Pisal, Sushenrao R. Patil, Chandrashekhar P. Mane, Dnyandeo N. Zambare
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4408955925