Kinetic analysis of drug release from Nateglinide-loaded ethyl cellulose nanoparticles for oral delivery
Year: 2024
Type: article
Abstract: With the objective to achieve sustained drug release, especially for the oral delivery and thereby to reduce the side effects of administration of conventional dosage form, Nateglinide (NTG)-loaded Ethyl cellulose (EC) nanoparticles have been formulated. These polymeric nanoparticles have been developed by solvent evaporation method and were subjected to in-vitro drug release analysis up to 12 hrs. The formulation demonstrated favourable in-vitro sustained release characteristics. Experimental in-vitro release data were substituted with available mathematical models to establish the mechanism of release of nateglinide and was found to follow Korsmeyer-Peppas release mechanism of diffusion from the polymeric matrix.
Authors: Gopi Govindasamy, Sundhararajan Ranganathan, Kannan Krishnamoorthy
Institution: Annamalai University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4408955952