Work

Transcriptomic studies of cardiovascular biology and pathology in the light of human pluripotent stem cell-derived cardiomyocytes

Year: 2024

Type: article

Abstract: The biological science owes its recent advancement to the generation of in vitro human cellsthrough differentiation of pluripotent stem cells. This breakthrough not only helped to revisit many known cellular processes, but also founded the basis for discovery of many unknown and unanswered questions. In this regard, human induced pluripotent stem cells-derived cardiomyocyte (hiPSC-CM) played a pivotal role in high throughput transcriptomic studies of cardiac physiology and pathology. From the molecular pathways governing the development of cardiovascular system to the very far mechanistic studies of heart-related diseases, were identified using transcriptomes of in vitro generated human cardiomyocytes. This review summarizes the important steps toward turning hiPSC-CM to a valuable platform for high throughput transcriptomic studies and the major findings obtained in the light of using this tool.

Source: Biomedicine Advances

DOI: 10.34172/bma.03

Authors: Mojtaba Shafaghi, Malihe Rezaee, Alireza Yaghoobi, Fatemeh Etezadi, Sara Pahlavan

Institution: Royan Institute

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Royan Institute