Work

Effects of Huluan decotion on cyclophosphamide-induced autoimmune premature ovarian failure in murine models.

Year: 2025

Type: article

Abstract: OBJECTIVES: To investigate the therapeutic effect of Huluan decotion (, HLD) on cyclophosphamide-induced premature ovarian failure (POF) in mice and its regulatory mechanisms. METHODS: immune-ohistochemical staining. The primary mechanism of POF were investigated through Western blot analysis. RESULTS: E2 levels decreased, and FSH and LH levels increased in POF model mice, but these trends were reversed with HLD or premarin administration, the expressions of WNT family member 4 (Wnt4), β-Catenin and FOXL2 were downregulated in POF model mice, whereas high expression levels were observed in control mice and other groups. CONCLUSION: HLD effectively treats POF induced with cyclophosphamide in mice by enhancing expressions of Wnt4, β-Catenin and FOXL2.

Source: PubMed

DOI: 10.19852/j.cnki.jtcm.20240927.001

Authors: Feng Guiling, Zhou Xiaolin, Shen Chengwan, L I Panxiao, Abulizi Abudula

Institutions: Ningde Normal University, Nanyang Medical College

Language: English

Topic: Reproductive Biology and Fertility

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4408956625