Electroacupuncture improves cyclophosphamide-induced bladder overactivity by reducing mechanotransduction in the rat urothelium.
Year: 2025
Type: article
Abstract: OBJECTIVE: To investigate whether electroacupuncture (EA) therapy for overactive bladder (OAB) exerts its effect by modulating mechanosensitive channels in the urothelium, thereby improving bladder sensory function. METHODS: urodynamic determination and Void spot assay. tissue morphology, distribution and expression of the TRPV4 protein and the amount of adenosine triphosphate (ATP) and Ca2+ released from urothelial cells in each group of rats were observed to identify the mechanism by which electroacupuncture improves OAB in rats. RESULTS: concentration and the release of ATP and acetylcholine (Ach) from bladder urothelial cells were inhibited. The changes in EA followed the same trend as those in HC-067047. CONCLUSIONS: and reduces the release of ATP and Ach, thereby attenuating excitatory signals.
Source: PubMed
Authors: H U Junwei, Feng Jiwei, L I Wen, Liu Lumin, L I Xu, X U Ge, Liu Jiandang, Chen Yuelai
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4408956734