Work

Low levels of soluble neuropilin‐1 were associated with depression in adults with newly diagnosed type 2 diabetes

Year: 2025

Type: article

Abstract: Aims To explore the association between soluble neuropilin‐1 (sNRP‐1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods Multicentre, cross‐sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR‐1 (low sNRP‐1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepressants, BMI, haemoglobin A1c, C‐peptide and pre‐existing cardiovascular disease. Multiple regression analyses were performed with depression and low sNRP‐1 as dependent variables. Results The study comprised 837 participants (18–94 years, younger patients <60 years 38%). Depressed patients ( n = 119) compared to non‐depressed ( n = 718) had a higher prevalence of anxiety (64% vs. 14%), antidepressants (36% vs. 14%), low sNRP‐1 (45% vs. 22%) (all p < 0.001); physical inactivity (42% vs. 29%, p = 0.006); smoking (20% vs. 12%, p = 0.018); and higher BMI ( p = 0.002). Independently associated with depression ( n = 736) were anxiety (adjusted odds ratio (AOR) 11.7, p < 0.001), low sNRP‐1 (AOR 3.3, p < 0.001), BMI (per kg/m 2 ) (AOR 1.1, p = 0.016) and physical inactivity (AOR 1.8, p = 0.018). In younger patients ( n = 288), independently associated with low sNRP‐1 were depression (AOR 3.3, p < 0.001), myocardial infarction (AOR 3.8, p = 0.039) and younger age (per year) (AOR 0.97, p = 0.043). In older patients ( n = 521), independently associated with low sNRP‐1 were depression (AOR 3.1, p < 0.001), and younger age (0.97, p = 0.030). Conclusions Low sNRP‐1 (<226 ng/mL) was associated with depression in all patients with newly diagnosed T2D. In younger patients (<60 years), depression, pre‐existing myocardial infarction and younger age were associated with low sNRP‐1. In older patients, only depression and younger age were associated with low sNRP‐1.

Source: Diabetes Obesity and Metabolism

DOI: 10.1111/dom.16347