Hypolipidemic effect and mechanism of Hedan tablet based on network pharmacology.
Year: 2025
Type: article
Abstract: OBJECTIVE: To examine Hedan tablet (HDT, )'s potential mechanisms in hyperlipidemic rats induced by a high-fat diet (HFD), as well as its regulatory effects and primary active constituents. METHODS: experiments. RESULTS: study confirmed that quercetin and kaempferol could reduce the levels of IL-6, IL1B, MMP9 and HMGCR in the high-fat model of hepatoma G2 cells. CONCLUSIONS: The mechanism by which HDT treats hyperlipidemia involves modification of the lipid metabolism targets such as downregulating SREBF2, HMGCR and MMP9, and upregulating PPAR-α and PPAR-γ, as well as anti-inflammatory and antioxidant actions. This study provides a pharmacological and biological rationale for the use of HDT in clinical hyperlipidemia management.
Source: PubMed
Authors: H U Huiming, Weng Jiajun, Tang Fangrui, Wang Yaqi, Fan Shengxian, Wang Xuecheng, Cui Can, Shao Feng, Zhu Yanchen
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4408957378