Comprehensive Review of Conservative and Surgical Treatment Strategies for Knee Osteoarthritis: Efficacy, Safety, and Emerging Therapies
Year: 2025
Type: article
Abstract: Knee osteoarthritis (KOA) is a chronic degenerative joint disorder that significantly impairs mobility and quality of life. While surgical interventions such as total knee arthroplasty (TKA) are effective in severe cases, conservative treatments are critical for early and intermediate disease management. This review evaluates the efficacy, safety, and clinical applications of both conservative and surgical treatment approaches, including lifestyle modifications, physical therapy, pharmacological interventions, regenerative medicine, and surgical procedures. The integration of a multidisciplinary approach is emphasized as a key strategy for optimizing clinical outcomes and tailoring interventions to disease severity.
Authors: Helder Rocha da Silva Araújo, Andrei Machado Viegas da Trindade, Thamara Cardoso Jacob, Geovana Goulart Ribeiro de Freitas, Samuel Ferreira Barbosa, Maria Tereza Guay de Goiás, Isabella Luiza das Graças Rocha Borges, Lucas Guzzi Silva, Fabiano Bottino Cançado, Fernanda Grazielle da Silva Azevedo Nora
Institutions: Universidade Federal de Goiás, Hospital de Base
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408963724