Work

Comparison of urinary tract-related and catheter-related bloodstream infections in long-term and acute care wards: A retrospective cohort study

Year: 2025

Type: article

Abstract: BACKGROUND: The characteristics of bloodstream infections in patients admitted to long-term care wards remain unclear. This study examined differences in nosocomial-onset urinary tract-related bloodstream infections (UTRBSIs) and catheter-related bloodstream infections (CRBSIs) between patients admitted to long-term and acute care wards. METHODS: This retrospective cohort study was conducted at a mixed-care hospital with long-term and acute care wards from April 2015 to March 2024. Patient backgrounds, causative pathogens, antibiotic resistance, and treatment patterns were compared between the two groups. RESULTS: Among the 252 patients, 108 (42.9 %) were diagnosed with UTRBSIs and 87 (34.5 %) with CRBSIs. In UTRBSIs, the long-term care group had significantly longer hospitalization (721 vs. 16 days, P < 0.001), more frequent use of indwelling urinary catheters (76.7 % vs. 28.6 %, P < 0.001), and higher isolation rates of extended-spectrum β-lactamase-producing Enterobacterales (41.1 % vs. 8.6 %, P < 0.001). Piperacillin/tazobactam and meropenem were significantly more frequently used empirically in the long-term care group. In CRBSIs, the isolation rates of main causative pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) (9.5 % vs. 6.7 %, P = 0.707) and methicillin-resistant coagulase-negative Staphylococcus spp. (40.5 % vs. 48.9 %, P = 0.519), showed no significant differences between the two groups despite differences in patient backgrounds. Anti-MRSA agents were rarely used empirically in both groups (19.0 % vs. 15.6 %, P = 0.779). CONCLUSIONS: Patients admitted to long-term care wards may require empirical therapy for UTRBSIs targeting drug-resistant Enterobacterales, while for CRBSIs, empirical use of anti-MRSA agents may be considered, similar to patients admitted to acute care wards.

Source: Journal of Infection and Chemotherapy

DOI: 10.1016/j.jiac.2025.102690

Authors: Kohei Kumagai, Ryo Inose, Asako Kimura, Yuichi Muraki

Institutions: Kyoto Pharmaceutical University, National Hospital Organization

Language: English

Topic: Urinary Tract Infections Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,650