Work

Closed-loop control of anesthesia using two-degrees-of-freedom control with a target-controlled infusion algorithm

Year: 2025

Type: article

Abstract: This article proposes a new closed-loop control method to induce and maintain a desired depth of hypnosis during total intravenous anesthesia. The method utilizes two-degrees-of-freedom control, with propofol infusion rate as the input and bispectral index (BIS) as the output. A target-controlled infusion (TCI) algorithm called STANPUMP is used as the feedforward action to achieve the desired BIS response, and a feedback controller based on a Kalman filter deals with model uncertainties. Adding a TCI algorithm as the feedforward action improves the time-to-target and enhances patient safety. This is because it allows for a seamless transition to open-loop control if needed.

Source: IFAC-PapersOnLine

DOI: 10.1016/j.ifacol.2025.03.063

Authors: Aleksander Vegelj, Igor Škrjanc, Gorazd Karer

Institution: University of Ljubljana

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Javna Agencija za Raziskovalno Dejavnost RS