Work

Digital twin development of yeast fed-batch cultures for vaccine production

Year: 2025

Type: article

Abstract: This paper reports on designing a digital twin of a yeast culture process in an industrial context. Using a rich experimental data set corresponding to different input profiles, an original dynamic model based on the assumption of cell overflow metabolism is derived. The kinetic laws are represented by smooth functions combining Monod and Jerusalimski factors, which model rate activation and inhibition, respectively. Parameter estimation is achieved following an iterative procedure including practical identifiability analyses which allow the design of informative experiments, enhancing parameter precision and accuracy.

Source: IFAC-PapersOnLine

DOI: 10.1016/j.ifacol.2025.03.067

Authors: Micaela Benavides, Pascal Gerkens, Gaël de Lannoy, Laurent Dewasme, Alain Vande Wouwer

Institutions: University of Mons, GlaxoSmithKline (Belgium)

Language: English

Topic: Control Systems and Identification

Subfield: Control and Systems Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: diamond

Funders: European Commission, Service Public de Wallonie, H2020 Marie Skłodowska-Curie Actions

OpenAlex ID: W4408969465

FWCI: 1.176

Cites: 18

Cited by: 3

Related to: 10