Comparative analysis of blood vessel morphometry in advanced oral submucous fibrosis and malignancy associated with oral submucous fibrosis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Oral submucous fibrosis (OSF) is a potentially malignant disorder of oral cavity. The vascularity of submucosa in this disease can predict its malignant transformation. Aim: In this study, attempts have been made to investigate different parameters of vascularity, such as mean vascular area, luminal diameter etc., in advanced OSF and make a comparison with malignancy associated with OSF. Materials and Methods: Incisional biopsy was taken from clinically diagnosed cases of advanced OSF and malignancy associated with OSF. Sections were prepared and stained with haematoxylin and eosin for histomorphometric analysis using a research microscope. Results: A statistically significant increase in mean vascular area and luminal diameter of blood vessels was noticed in malignancy associated with OSF compared to advanced OSF. Conclusion: To support the nutritional demand of carcinogenesis, increased blood supply is required; hence blood supply increased in the form of budding blood vessels or enlarged dilated blood vessels. These changes can be used as a predictive marker for this transformation.
Authors: Tathagata Bhattacharjee, Supratim Ghosh, Dipto De, Pratik Sarkar, Jay Gopal Ray
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4408975238