Work

Study of the Elevation of Galectin-3 Level in Plasma Patients with Inflammatory Bowel Disease in Babylon Province

Year: 2025

Type: article

Abstract: Background: Inflammatory bowel disease is a collection of illnesses that mainly affect the colon and small intestine, the most prevalent types being Crohn’s disease and ulcerative colitis. Carbohydrate-binding proteins (also known as galectins) have been shown to play an essential role in the regulation of both innate and adaptive immune responses. Objective: The aim of this study was to measure the amount of galectin-3 and look at any potential links between the protein and iron, and vitamin E in inflammatory bowel illness in Babylon province. Materials and Methods: Galectin-3 levels were evaluated in 100 people: 50 with inflammatory bowel disease and 50 with healthy people. The study participants and the healthy controls varied in age from 15 to 65. The enzyme-linked immunosorbent assay (ELISA) method measured Galectin-3 and vitamin E while Iron was in the spectrophotometer in the serum. Results: The serum Galectin-3 was greater in IBD patients than in controls ( P = 0.01). In contrast, the current study discovered a negative association between Galectin-3 and iron in IBD patients ( P = 0.05) and a non-significant relationship between Galectin-3 and vitamin E in IBD patients ( P > 0.05). Conclusion: There is a significant association between IBD and high Galectin-3 levels in Babylon province patients.

Source: Medical Journal of Babylon

DOI: 10.4103/mjbl.mjbl_271_23

Authors: Arkan Khanjar Nasrullah, Ban Mahmood Shaker Al-joda, Hassan Salim Aljumaily

Institution: University of Babylon

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200