Work

MicroRNA-124-3p and Brain-derived Neurotrophic Factor in Rat Spinal Cord Injury: Inverse Expression Pattern

Year: 2025

Type: article

Abstract: Spinal cord injury (SCI) significantly impacts the central nervous system, with limited effective treatments available. Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal growth, survival, and regeneration after SCI. MicroRNAs, particularly miR-124-3p, have been implicated in SCI pathophysiology. However, the relationship between miR-124-3p and BDNF in the context of SCI remains unclear. This study aimed to investigate the correlation between miR-124-3p expression and BDNF levels in a rat model of spinal cord injury and to assess how the timing of injury affects this relationship.

Source: Gene Expression

DOI: 10.14218/ge.2024.00073

Authors: Maryam Zand, Mehdi Sadegh, Behzad khansarinejad, Mahdieh Mondanizadeh

Institutions: Arak University of Medical Sciences, Arak University

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Arak University of Medical Sciences