The effect of Botox Injections on Wound Healing Before and after Surgery
Year: 2025
Type: article
Abstract: This study aimed to examine the effects of Botox therapy on the skin's wound regeneration in patients who received the treatment before or after surgery. We used 18 male albino rats weighing between 250 and 350 grams, each getting 1 IU of Botox and saline injected in the subcutaneous muscle in the center of 1.5 cm circles with 4.5 cm between them in the dorsum of each rat. In group A, the injection was seven days before surgery, and the animals had a full-thickness skin excision; in group B, the injection was immediately after wound incidence, and all were kept in separate cages. Each group was divided into three equal subgroups according to the healing period (3, 7, and 14 days), and then histological tests were undertaken on skin biopsies for all the groups post-euthanasia. The results showed significant differences between groups A and B On day three, group A exhibited mild inflammation, whereas group B and both control groups had severe inflammation. On day 7, group A had scanty granulation tissue and re-epithelialization of more than half of the lesions. Group B had greater granulation tissue and less re-epithelialization. On day 14, both groups exhibited considerable granulation tissue growth, but group A had increased blood vessels and keratinocyte proliferation, which resulted in extremely good re-epithelialization and skin regeneration. We recommend that Botox injections be considered an effective alternative treatment option to accelerate wound healing, and the most suitable method to administer Botox is before surgery.
Authors: Hisham Abid Ahmed, Abdulhameed N. Aldabagh, Abdulsattar Salim Mahmood
Institution: University of Mosul
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408985107