Work

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Year: 2025

Type: article

Abstract: Lanthanide‐based luminescence nanothermometry has demonstrated unprecedented advantages in the development of nanotheranostic platforms for potential medical applications, yet despite exponential research progress and great enthusiasm across various related disciplines, a swift bench‐to‐bedside translation seems to be still out of reach. This is predominantly related to fundamental research issues at the preclinical stage, such as complex nanomaterials design, incomplete optimization, fragmented characterization, and insufficient validation of nanothermometer performance in physiological environments. The main impediments currently are important biophysicochemical issues that must be addressed comprehensively, first and foremost in available in vitro systems, before going on to in vivo investigations. This review outlines a critical perspective, as well as a route of suggestions and underexplored aspects to address and significantly minimize the existing translational gap.

Source: Advanced NanoBiomed Research

DOI: 10.1002/anbr.202500003

Authors: Simona Premcheska, Andre G. Skirtach, Anna M. Kaczmarek

Institution: Ghent University

Language: English

Topic: Luminescence Properties of Advanced Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,940