Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study
Year: 2025
Type: article
Abstract: Introduction: Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach. Methods: At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months. Results: AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance. Discussion: -amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
Source: Frontiers in Aging Neuroscience
Institutions: Inserm, Cyceron, Physiopathologie et imagerie des troubles neurologiques, Université de Caen Normandie, Centre Hospitalier Universitaire de Caen Normandie, University of Liège, German Center for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Dresden, University College London
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4408991170