Relationship Between the Elastic Modulus of the Novel Pedicle Screw-Plate System and Biomechanical Properties Under Osteoporotic Condition: A Power-Law Regression Analysis Based on Parametric Finite Element Simulations
Year: 2025
Type: article
Abstract: BACKGROUND AND OBJECTIVE: The novel pedicle screw-plate system (NPSPS) is a new internal fixation method for the thoracic spine that we proposed, which has demonstrated effectiveness through clinical practice and biomechanical testing. Nevertheless, the optimal elastic modulus of NPSPS (NPSPS-E) remains debated, particularly for osteoporosis patients. We propose a more efficient method to predict the biomechanical effects of NPSPS across varying elastic moduli in osteoporosis using parametric finite element (FE) analysis, establishing the regression relationship between NPSPS-E and biomechanical properties. METHODS: An FE surgical model of NPSPS under osteoporotic conditions was developed. The NPSPS-E was linearly varied from 3.6 GPa (polyether ether ketone) to 110 GPa (titanium alloy). Using power-law regression analysis, a functional equation was established to correlate NPSPS-E with biomechanical properties under osteoporotic condition. RESULTS: Power-law equations and regression models were successfully established between NPSPS-E and biomechanical prediction indices under osteoporotic condition (P<0.0001). As NPSPS-E increased, the range of motion (ROM) of the T8-T10 spinal segments decreased from 0.51°-4.06° to 0.24°-1.45°. The mean von Mises stress in the T8-T10 vertebrae declined from 1.36 MPa-2.03 MPa to 1.15 MPa-1.79 MPa. Concurrently, the stress shielding ratios and the total stress ratios of the NPSPS increased from 3.66%-48.07% and 13.96%-26.96% to 10.70%-56.20% and 52.62%-64.40%, respectively. CONCLUSION: The functional equations derived from these models serve as a predictive tool to directly estimate the biomechanical effects of NPSPS across a range of elastic modulus under osteoporotic conditions, thereby facilitating the design and optimization of NPSPS materials.
Authors: Kaibin Wang, Chongyi Wang, Haipeng Si, Yanwei Zhang, Shaowei Sang, Runtong Zhang, Wencan Zhang, Junfei Chen, Chen Liu, Kunpeng Li, Bingtao Hu, Xiangyu Lin, Yunze Feng, Qingyang Fu, Zhihao Kang, Mingyu Xu, Dingxin Zhang, Wanlong Xu, Le Li
Institutions: Shandong University, Qilu Hospital of Shandong University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,350
Awards: G4866401609, G5624336127, G7140896570
OpenAlex ID: W4408992881