PCD-CTVersusEID-CT in Imaging of Pancreatic Ductal Adenocarcinoma: A Prospective Comparative Pilot Study
Year: 2025
Type: article
Abstract: BACKGROUND/AIM: Photon-counting detector computerised tomography (PCD-CT) is a novel imaging technique that may be beneficial in diagnostics and follow-up of pancreatic ductal adenocarcinoma (PDAC). PATIENTS AND METHODS: A prospective pilot including eight patients with confirmed PDAC was designed. Patients underwent conventional energy integrating detector CT (EID-CT) and PCD-CT, and corresponding arterial and venous phase images were compared in quantitative and qualitative manners. Five independent and method blinded reviewers scored each intra-individual pair of images. RESULTS: =0.003, 0.001, and 0.040, respectively). There was a non-significant tendency towards better edge sharpness in the PCD-CT images. Qualitative assessments of image quality revealed minor differences in some aspects of arterial phase, favouring the conventional EID-CT, however no statistically significant differences in terms of overall or venous phase parameters between the methods were evident. CONCLUSION: PCD-CT offers a novel method with potential benefits in imaging of pancreatic tumours. Further development of the protocol, including optimisation and validation in larger cohorts of patients, are necessary to define a potential role of PCD-CT in the management of PDAC.
Source: Anticancer Research
Authors: HAKON BLOMSTRAND, ERIK TESSELAAR, BERGTHOR BJÖRNSSON, WOLF BARTHOLOMÄ, TOMAS BJERNER, MICHAEL SANDBORG, NILS O. ELANDER, MISCHA WOISETSCHLÄGER
Institutions: Linköping University, Linköping University Hospital
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4408997655