Work

An Amplitude Analysis-Based Magnetoelastic Biosensing Method for Quantifying Blood Coagulation

Year: 2025

Type: article

Abstract: Blood coagulation tests are crucial in the clinical management of cardiovascular diseases and preoperative diagnostics. However, the widespread adoption of existing detection devices, such as thromboelastography (TEG) instruments, is hindered by their bulky size, prohibitive cost, and lengthy detection times. In contrast, magnetoelastic sensors, known for their low cost and rapid response, have garnered attention for their potential application in various coagulation tests. These sensors function by detecting resonant frequency shifts in response to changes in blood viscosity during coagulation. Nevertheless, the frequency-based detection approach necessitates continuous and precise frequency scanning, imposing stringent demands on equipment design, processing, and analytical techniques. In contrast, amplitude-based detection methods offer superior applicability in many sensing scenarios. This paper presents a comprehensive study on signal acquisition from magnetoelastic sensors. We elucidate the mathematical relationship between the resonant amplitude of the response signal and liquid viscosity, propose a quantitative viscosity measurement method based on the maximum amplitude of the signal, and construct a corresponding sensing device. The proposed method was validated using glycerol solutions, demonstrating a sensitivity of 13.83 V−1/Pa0.5s0.5Kg0.5m−1.5 and a detection limit of 0.0817 Pa0.5s0.5Kg0.5m−1.5. When applied to real-time monitoring of the coagulation process, the resulting coagulation curves and maximum amplitude (MA) parameters exhibited excellent consistency with standard TEG results (R2 values of 0.9552 and 0.9615, respectively). Additionally, other TEG parameters, such as R-time, K-time, and α-angle, were successfully obtained, effectively reflecting viscosity changes during blood coagulation.

Source: Biosensors

DOI: 10.3390/bios15040219

Authors: Xi Chen, Qiong Wang, Jinan Deng, Ning Hu, Yanjian Liao, Jun Yang

Institutions: Chongqing University, Chongqing Medical and Pharmaceutical College

Language: English

Topic: Magnetic Properties and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,654

Funder: National Natural Science Foundation of China