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The effect of interleukin-15 on bovine natural killer and CD8+ T cells and its potential in treating viral infections

Year: 2025

Type: article

Abstract: Interleukin-15 (IL-15) is a promising cytokine for immunotherapy of human cancers and bovine viral infections. IL-15 indirectly has a negative effect on tumor and virus-infected cells by activating the signaling pathways of proliferation and activation of natural killer (NK) and memory CD8+ T cells. IL-15 therapy may have widespread clinical use, particularly when combined with chimeric antigen receptor (CAR) T or CAR NK cells. Additionally, the use of IL-15 in combination with checkpoint inhibitors and other therapies holds promise as a treatment for cancer and viral infections. Understanding the biological characteristics of IL-15 is crucial for developing effective therapeutic strategies. This study aimed to explore recent advances in IL-15 research, focusing on its antitumor mechanisms within the tumor microenvironment, advances in IL-15-based therapies for bovine viral infections, and its integration with other treatment approaches, including monoclonal antibodies.

Source: HERALD OF SCIENCE OF S SEIFULLIN KAZAKH AGRO TECHNICAL RESEARCH UNIVERSITY Veterinary sciences

DOI: 10.51452/kazatuvc.2025.5(009).1816

Authors: K.N. Mukantayev, Tursunov K. A. Tursunov, Zh. B. Adish, D. B. Kanayev, L. А. Tokhtarova, M. Nurtleu, B. E. Abirbekov

Institutions: National Center for Biotechnology, Centro Nacional de Biotecnología

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408999149

FWCI:

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