Work

Acetals in amidoalkylation of phosphonous carboxylic acids

Year: 2025

Type: article

Abstract: The use of free phosphonous carboxylic diacids in three-component carbamate version of the Kabachnik--Fields reaction in acetyl chloride medium allows introducing acetals into the reaction sphere to result in phosphinic peptides. The employment of low-stable and functionally substituted aldehydes in the form of acetals provides phosphinic peptides that are difficult to obtain by other methods.

Source: Mendeleev Communications

DOI: 10.71267/mencom.7650

Authors: Sofia R Golovash, Dmitry E Ivanov, Alexey V Borodachev, Sergey V Simonov, Maxim E Dmitriev, Valery Vladimirovich Ragulin

Institutions: Russian Academy of Sciences, Institute of Physiologically Active Compounds, Osipyan Institute of Solid State Physics RAS

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Russian Science Foundation

Award: G1545582793