Extramedullary hematopoiesis in primary myelobrosis presenting as upper gastrointestinal bleed
Year: 2025
Type: article
Study design: Case Report
Abstract: Primary myelofibrosis is a myeloproliferative neoplasm characterized by clonal proliferation of myeloid cells, megakaryotic proliferation, bone marrow fibrosis, extramedullary hematopoiesis (EMH) and leukoerythroblastosis. It is often due to JAK 2, MPL, or CAL mutations, though other mutations can also cause the disease. Patients usually present with severe fatigue, features of a hypermetabolic state, splenomegaly, and variable blood counts. EMH is also frequent in myeloproliferative neoplasm. It can arise anywhere in the body, even though the most involved sites are the liver, lymph nodes, and spleen. Risk stratification is done for prognosis and treatment initiation. Allogenic transplantation is the only curative treatment option for high-risk cases. Frequent transfusion requirements can arise in case of leukemic transformation, hypersplenism, or upper gastrointestinal (GI) bleeding. Here, we present a case of EMH in the GI tract presenting with an upper GI bleed.
Authors: Teena Nelson, Gayatri Gopan, Ravindran Anoop, Betty Abraham
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4409003853