Work

Kikuchi-Fujimoto disease, case report

Year: 2025

Type: article

Abstract: Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare, benign, and self-limiting condition characterized by subacute necrotizing cervical lymphadenopathy. Diagnosed through excisional lymph node biopsy, KFD predominantly affects young adults, especially females, with a higher incidence in Asian populations. The case discussed involves a 17-year-old male from Nayarit, Mexico, presenting with recurrent cervical lymphadenopathy unresponsive to antibiotics. Physical examination and imaging suggested lymphoproliferative disease, while biopsy confirmed histiocytic necrotizing lymphadenitis. Immunohistochemistry revealed CD68 positivity. KFD’s aetiology is unclear, with infectious and autoimmune theories proposed. The disease commonly resolves within 4 to 6 months with symptomatic management, including antipyretics and analgesics. This case is notable due to the patient’s young age, large lesion size, and male gender, diverging from the typical presentation, underscoring the importance of considering KFD as a differential diagnosis to avoid unnecessary invasive procedures.

Source: Oxford Medical Case Reports

DOI: 10.1093/omcr/omae211

Authors: Juan M Castañeda Martinez, Jose J I Y Zamora Diaz, Alison A Rodriguez Avila, Sandra B Somarriba Dominguez, Luis A Nava Fuentes

Institutions: Institute for Social Security and Services for State Workers, Universidad Nacional Autónoma de México, Universidad Autónoma de Guerrero, Universidad Autónoma de Nayarit

Language: English

Topic: Lymphadenopathy Diagnosis and Analysis

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,103