Work

Encapsulation of a Probiotic Bacterial Strain in a Biocompatible Iron(III) Fumarate Matrix

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The encapsulation of bacteria in metal–organic frameworks (MOFs) is being studied for use in biomedicine and bioremediation. However, biocompatibility could be improved, as much of the research focuses on ZIF-8 and Escherichia coli . MIL-88A, composed of fumaric acid and iron, offers a safer alternative. This study investigates encapsulation of the probiotic strain Lactiplantibacillus plantarum 299v in a nanocrystalline matrix via a simple one-pot synthesis. The encapsulated bacteria show improved stability in saline, lysozyme and pepsin compared to uncoated cells. These findings highlight the potential of the iron(III) fumarate matrix for bacterial protection and controlled release for biological applications.

Source: ACS Applied Bio Materials

DOI: 10.1021/acsabm.4c01398

Authors: Laura I. FitzGerald, Ashley L. Sutton, Cara M. Doherty

Institutions: Commonwealth Scientific and Industrial Research Organisation, CSIRO Manufacturing

Language: English

Topic: Metal-Organic Frameworks: Synthesis and Applications

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500