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Pancreatic Enzyme Replacement Therapy: Background, Indications, and Pitfalls

Year: 2025

Type: article

Abstract: This review outlines the history, physiology, clinical circumstances, pharmacology, pitfalls and proper implementation of exogenous pancreatic enzyme replacement therapy (PERT). Humanity has used PERT for hundreds of years--but in the last 30-50 years with much improved precision. Some topics that will be reviewed here include the complex diagnosis, prevalence, and long-term complications of Exocrine Pancreatic Insufficiency (EPI) and resultant dysfunction in Digestive Capacity (DC). The indications, efficacy, and safety of PERT in Exocrine Pancreatic Insufficiency (EPI). Optimizing PERT is not as easy as it seems. Many practical tips for PERT optimization are outlined for the reader.

Source: SMART-MD journal of precision medicine.

DOI: 10.69734/gqsbgc07

Author: John Lieb II

Institution: University of Florida

Language: English

Topic: Pancreatitis Pathology and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4409015861

FWCI: 0.892

Cites:

Cited by: 1

Related to: 10