Fentanyl versus dexmedetomidine during awake-fibreoptic intubation
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Awake-fiberoptic intubation is considered the gold standard technique for managing an anticipated difficult airway. Therefore, it is of interest to compare and evaluate fentanyl and dexmedetomidine on intubation conditions during awake-fiberoptic intubation. Hence, 90 patients were randomly divided into two groups, namely Group D and Group F, each consisting of 45 individuals. They were given Dexmedetomidine (1 mcg/kg over 10 minutes) and fentanyl (2 mcg/kg over 10 minutes) followed by monitoring and recording using Ramsay sedation scale at every 2 minutes, 5 minutes, 10 minutes and 20 minutes. Parameters like systolic blood pressure, diastolic blood pressure and heart rate were noted. They found that, the differences are not statistically significant as time advances following intubation, even though dexmedetomidine contributes to the maintenance of a lower systolic blood pressure. Further, the efficacy of dexmedetomidine in reducing diastolic blood pressure is more pronounced; however, following intubation, the disparities between the two groups diminish and it is not statistically significant. Thus, in comparison to fentanyl, dexmedetomidine demonstrates superior efficacy in the management of heart rate both during and immediately following intubation.
Source: Bioinformation
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4409018634