Comparative analysis of postoperative pain with glycolic acid vs. ethylenediaminetetraacetic acid in endodontic treatment: A randomized clinical trial
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: The aim of this study was to evaluate pain and analgesic intake after endodontic treatment using glycolic acid (GA) or ethylenediaminetetraacetic acid (EDTA) as the final irrigating solution.Material and Methods: One hundred fifty patients were randomly assigned to two groups for smear layer removal: 17% GA or 17% EDTA.Postoperative pain was assessed at 24, 48 hours and 7 days.The need for analgesic intake was recorded.Descriptive analysis was performed to assess demographics (Student t, Chi-square and Fisher tests) and study outcomes (Mann Whitney, Friedman and Nemenyi) (p<0,05).Results: Postoperative pain occurred in 52% of the cases.In the 24-hour period, GA had a significantly lower pain score (p <0.05).There was no statistical difference between the groups regarding the use of analgesic pills.Conclusions: GA is associated with less postoperative pain at 24 hours compared to EDTA.No statistically significant difference was observed at 48 hours and 7 days.
DOI: 10.4317/jced.62446
Institution: Universidade de Passo Fundo
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409021091