Work

The Effect of COVID‐19 on Platelet Counts in Persistent and Chronic Adult ITP Patients: A Real‐World Study in China

Year: 2025

Type: article

Abstract: Objective: While coronavirus disease 2019 (COVID-19)-associated thrombocytopenia is well-documented, its effects on immune thrombocytopenia (ITP) patients remain unclear. This study aimed to investigate the impact of COVID-19 infection on platelet (PLT) dynamics in chronic ITP patients. Methods: This retrospective study analyzed 21 persistent and chronic ITP patients before and after mild COVID-19 infection during China's December 2022 reopening, comparing platelet parameter changes with a focus on clinical characteristics of thrombopoietin receptor agonist (TPO-RA) treated patients. Results: TPO-RA treated patients demonstrated transient platelet surges peaking at 1 week postinfection, returning to baseline within 2-3 weeks, contrasting sharply with thrombocytopenia patterns in non-ITP populations. This suggests synergistic effects between virus-induced inflammatory cytokines and TPO-RA may drive transient megakaryopoiesis. Conclusion: These findings underscore infection-related PLT fluctuations in ITP, necessitating monitoring for thrombotic and bleeding risks and TPO-RA dose optimization during infections. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.

Source: eJHaem

DOI: 10.1002/jha2.70025

Authors: Yujiao Zhang, Lei Yang, Zhongping Xu, Xin Zhou

Institutions: Wuxi People's Hospital, Nanjing Medical University

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,860