Work

Detection of vanA genes in vancomycin-susceptible Enterococcus faecium isolates: implications for additional testing

Year: 2025

Type: article

Abstract: To assess the frequency of silent vancomycin resistance, phenotypically susceptible E. faecium isolates underwent genotypic testing using Cepheid’s Xpert vanA/vanB PCR. 6% of isolates had silent vanA genes. However, the clinical relevance of silent van genes, and the lack of rapid, random-access genotypic methods poses an ongoing challenge to laboratories.

Source: Access Microbiology

DOI: 10.1099/acmi.0.000959.v4

Authors: Victoria Jordan, Hemalatha Varadhan

Institutions: John Hunter Hospital, NSW Health Pathology, University of Newcastle Australia

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $858