Work

Polydopamine-Coated Copper-Doped Mesoporous Silica/Gelatin–Waterborne Polyurethane Composite: A Multifunctional GBR Membrane for Bone Defect Repair

Year: 2025

Type: article

Abstract: Guided bone regeneration (GBR) membrane has proven to be a fundamental tool in the realm of bone defect repair. In this study, we develop a mussel-inspired composite biomaterial through polydopamine-assisted, combining gelatin–WPU matrix with the ion-release behavior of Cu–MSNs for augmented bone regeneration. The optimized composite membrane exhibits enhanced mechanical stability, demonstrating a tensile strength of 11.23 MPa (representing a 2.3-fold increase compared to Bio-Gide®), coupled with significantly slower degradation kinetics that retained 73.3% structural integrity after 35-day immersion in physiological solution. Copper ions act as angiogenic agents to promote blood vessel growth and as antimicrobial agents to prevent potential infections. The combined effect of these components creates a biomimetic environment that is ideal for cell adhesion, growth, and differentiation. This research significantly contributes to the development of advanced biomaterials that combine regeneration and infection-prevention functions. It provides a versatile and effective solution for treating bone injuries and defects, offering new hope for patients in need.

Source: Journal of Functional Biomaterials

DOI: 10.3390/jfb16040122

Authors: Mengmeng Jin, Yi Hou, Feiwu Kang

Institutions: Tongji University, Sichuan University, State Key Laboratory of Oral Diseases

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258