Catalytic asymmetric construction of 1,5-remote Si- and C-stereocenters via desymmetrizing ene reaction of bis(methallyl)silanes
Year: 2025
Type: article
Abstract: desymmetrization is particularly difficult. Herein, we realized an example of a chiral nickel(ii) complex-catalyzed desymmetrizing carbonyl-ene reaction of bis(methallyl)silanes with α-keto aldehyde monohydrates, enabling the highly chemo-, diastereo- and enantioselective synthesis of chiral δ-hydroxy silanes featuring 1,5-remote Si- and C-stereocenters. This protocol demonstrated good functional group tolerance and a broad substrate scope. A bioactivity study revealed its potential applications in the synthesis of bioactive molecules.
Source: Chemical Science
DOI: 10.1039/d5sc01054c
Authors: Qiuhui Cao, Yuntian Yang, Yiwen Mei, Minghui Ji, Fei Wang, Xiaoming Feng, Weidi Cao
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
Awards: G110546401, G1188701664, G615878642
OpenAlex ID: W4409046443