Optimized Synthesis of Dinitrochalcones via Ultrasonic Bath in a Cyclohexane–Methanol Solvent System
Year: 2025
Type: article
Abstract: This study describes the efficient synthesis of five dinitrochalcones (DNCH) using an ultrasonic bath as an unconventional method to improve reaction yields and reduce reaction times. The Claisen-Schmidt condensation of nitroacetophenones and nitrobenzaldehydes was carried out in a cyclohexane-methanol solvent system under ultrasonic irradiation, achieving yields between 56% and 92%. The application of ultrasound not only accelerated the reaction but also improved the overall efficiency compared to conventional methods such as magnetic stirring. Characterization of the synthesized compounds was performed by NMR spectroscopy, confirming the consistency of their structures. Thus, it is confirmed that obtaining DNCH with a nitro group in ortho provide by ultrasonic irradiation is an energetically efficient and environmentally friendly alternative.
Source: Organics
DOI: 10.3390/org6020014
Institution: Universidad Juárez Autónoma de Tabasco
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,207
OpenAlex ID: W4409049749