Work

Ocrelizumab-Related Organizing Pneumonia: A Rare Pulmonary Complication in Multiple Sclerosis

Year: 2025

Type: article

Abstract: We report a case of organizing pneumonia induced by ocrelizumab in a 65-year-old man with multiple sclerosis. The patient presented with persistent fever and progressive respiratory symptoms despite broad-spectrum antibiotic treatment. Chest imaging revealed diffuse ground-glass opacities, and a transbronchial biopsy confirmed organizing pneumonia. Corticosteroid therapy led to marked clinical improvement, and ocrelizumab was discontinued. This case highlights the importance of recognizing drug-induced organizing pneumonia in patients receiving immunomodulatory therapy, particularly when standard antibiotic treatments fail. Early identification and corticosteroid intervention are critical to avoid further complications.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2024.1069

Authors: Neria Bitton, Swetha Rayaroth, Anuraj Mambazhathu Sudhakaran, Eli Zolotov

Institutions: Geisinger Medical Center, Hackensack University Medical Center

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409050029