Work

Phenyl thiosemicarbazide cyclization leads to the versatile 1,3,4-thiadiazole scaffold: Structural analysis of its copper(I) complex

Year: 2025

Type: article

Abstract: • Novel 2-phenylamino-1,3,4-thiadiazole synthesized via unexpected cyclization. • The coordination of the thiadiazole scaffold towards Cu(I) is investigated. • The 1D polymeric structure of the complex is analysed by X-ray diffraction. • The complex exhibits solid-state white emission. In an attempt to extend the synthesis of N,N-dialkyl formamidines to thiosemicarbazides, we unexpectedly obtained 2-phenylamino-1,3,4-thiadiazole as the cyclization product. Since the coordination chemistry of this versatile scaffold is poorly investigated, we have examined its interaction with CuI, resulting in the isolation of a novel 1D coordination polymer. In this polymer, each copper(I) ion is coordinated to two nitrogen atoms from two different 1,3,4-thiadiazole ligands, along with two iodide ions, forming a distorted tetrahedral geometry. Notably, the copper(I) complex exhibits solid-state white emission.

Source: Inorganic Chemistry Communications

DOI: 10.1016/j.inoche.2025.114432

Authors: Alessio Zavaroni, Giorgio Pelosi, Matteo Incerti, Mauro Carcelli, Dominga Rogolino

Institution: University of Parma

Language: English

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,550

Funders: Chiesi Farmaceutici, Ministero dell’Istruzione, dell’Università e della Ricerca, Università degli Studi di Parma