Effect of Ajwa dates on quality of life and serum tumour necrosis factor-alpha levels in patients with schizophrenia treated with risperidone: a randomised controlled study
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: OBJECTIVES: ) on quality of life (QoL) and serum tumour necrosis factor-alpha (TNF-α) levels in patients with schizophrenia treated with risperidone. METHODS: Consecutive hospitalised patients aged 20 to 45 years who were diagnosed with schizophrenia, treated with risperidone at 4 to 6 mg/day, with a disease onset of ≤5 years, and had passed the acute phase were invited to participate. Participants were randomly and equally assigned to either the treatment or control group. The treatment group received risperidone as prescribed and seven Ajwa dates per day (ie, 60-80 g), whereas the control group received risperidone alone. Patient QoL was assessed by a psychiatrist in face-to-face interviews using the World Health Organization Quality of Life Brief Version (WHOQOL-BREF) at baseline, week 4, and week 8. Serum TNF-α levels were assessed using the enzyme-linked immunosorbent assay at baseline and week 8. RESULTS: = -0.918, p < 0.001) groups. CONCLUSION: Ajwa dates have an adjuvant effect on improving QoL and reducing serum TNF-α levels in patients with schizophrenia treated with risperidone.
DOI: 10.12809/eaap2455
Authors: Rismayanti, Limoa Erlyn, Syamsuddin Saidah, Seweng Arifin, Andi Mappaware Nasrudin, Renaldi Rinvil, Lisal Sonny Teddy
Institution: Hasanuddin University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409055489