Work

Synthesis and Elaboration of Medium-Sized Ring Building Blocks Prepared via Cascade Ring Expansion Reactions

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A general approach is described for the synthesis and elaboration of medium-sized ring mono- and difunctionalized 8- or 9-membered ring lactone building blocks. The lactones are prepared via cascade ring expansion reactions and elaborated via Suzuki–Miyaura cross coupling and various N -functionalization reactions. This enables efficient access to diverse, medium-sized ring building blocks in a synthetically challenging and under-represented area of the pharmaceutical chemical space.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c00202

Authors: Haimei Zhou, Peter O’Brien, William P. Unsworth

Institution: University of York

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: University of York