Work

Mathematical Modeling of Brucellosis Transmission Dynamics and Its Age‐Specific Applications

Year: 2025

Type: article

Abstract: Brucellosis remains a significant public health and economic burden, especially in developing nations where livestock–human interactions are frequent. This paper presents a partial differential equation (PDE) model to capture the transmission dynamics of brucellosis, with a focus on age‐specific impacts in humans and domestic animals. Using the integrated semigroup approach, the positivity and boundedness of the model were established ensuring biologically meaningful solutions. The basic reproduction number ( R 0 ) was derived through the Lotka–Sharpe–McKendrick integral equation, and the disease‐free equilibrium (DFE) was proven to be locally asymptotically stable when R 0 < 1. Global sensitivity analysis was performed using the PAWN method to identify key parameters influencing disease dynamics. Results revealed that humans aged 0–72 years are carriers of the disease, while domestic animals, particularly those aged 0–5 and 11–15 years, act as significant reservoirs. Furthermore, environmental contamination was found to be a critical driver of transmission, emphasizing the urgent need for improved sanitation and hygiene measures. This study underscores the importance of targeting specific age groups and addressing environmental factors to enhance brucellosis control strategies, providing valuable insights for policymakers and public health practitioners.

Source: Abstract and Applied Analysis

DOI: 10.1155/aaa/6552487

Authors: Innocent Sosoma, Eunice Mureithi, Nyimvua Shaban Mbare

Institution: University of Dar es Salaam

Language: English

Topic: Mathematical and Theoretical Epidemiology and Ecology Models

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,130